Search on: ISLETS OF LANGERHANS 
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Descriptor English:   Islets of Langerhans 
Descriptor Spanish:   Islotes Pancreáticos 
Descriptor Portuguese:   Ilhotas Pancreáticas 
Synonyms English:   Cell, Islet
Cells, Islet
Endocrine Pancreas
Islet Cell
Islet, Pancreatic
Islets, Pancreatic
Langerhans Islands
Langerhans Islets
Nesidioblast
Pancreatic Islet
Islands of Langerhans
Islet Cells
Nesidioblasts
Pancreas, Endocrine
Pancreatic Islets  
Tree Number:   A03.734.414
A06.407.414
Definition English:   Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN. 
Indexing Annotation English:   do not confuse with LANGERHANS CELLS (skin); neoplasms = ADENOMA, ISLET CELL or CARCINOMA, ISLET CELL or their specifics
Entry Combination - descr/qualif English:   Islets of Langerhans/transplantation use Islets of Langerhans Transplantation
 
History Note English:   91; was ISLANDS OF LANGERHANS 1963-90 
Allowable Qualifiers English:  
AB abnormalities AH anatomy & histology
BS blood supply CH chemistry
CY cytology DG diagnostic imaging
DE drug effects EM embryology
EN enzymology GD growth & development
IM immunology IN injuries
IR innervation ME metabolism
MI microbiology PS parasitology
PA pathology PH physiology
PP physiopathology RE radiation effects
SE secretion SU surgery
UL ultrastructure VI virology
Record Number:   29211 
Unique Identifier:   D007515 

Occurrence in VHL:
 

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